In 1895, Character builds a hotel in Transylvania, unseeable from the humans, to improve his dearest daughter Thrush in a innocuous environment. In the here days, the site is the Hotel Transylvania, where monsters modify their families to pay leisure far from the frightening humans. Character invites his friends - Character and his woman Eunice; Histrion and Wanda, the werewolves; Griffin, the undetectable man; Lexicographer, the mummy; the Sasquatch, among others - to meet the 118th birthday of Mavis. When the party is ready to act, the 21-year-old Jonathan is locomotion through the plant and stumbles at the hotel. Dracula sees Jonathan and disguises him as a mutant to skin Jonathan from the guests. But Mavis also sees Jonathan and Character forces him to sit of a fiend. Soon Thrush believes that Jonathan is the zing of her history despite the advices of her priest almost the humans.